There is a small risk of Toxic Shock Syndrome (TSS) associated with tampon use. TSS is a very rare disease, but you are at a higher risk of TSS if a tampon stays in your vagina longer than 8 hours. Signs of TSS include sudden high fever, vomiting, diarrhea, sunburn-like rash, dizziness, and muscle aches. If you experience one or more of these warning signs, remove your tampon immediately and consult your doctor. To reduce the risk of TSS, always use a tampon with the least amount of absorbency for your needs. You can also reduce the risk of TSS by alternating your tampon use with feminine sanitary pads. And remember to change your tampon every 4 to 8 hours.